Answers to keep your research moving.

Prime is a general diffusion-NMR environment with configurable methods, calibration and R&D modules. ResinAtOnce focuses on resins, their components and reporting workflow. They share parts of the scientific core, but a resin calibration does not become universal in Prime.

This update documents Prime 0.10.1 and preserves existing distribution. It does not add a public installer or change access terms. See Software & code for availability; if you have a package, use the guide matching your executable.

The application uses WPF on 64-bit Windows. The self-contained package includes the .NET runtime. Local C# methods need no MATLAB, Python or HTTP connection. External engines and AI models have their own requirements; no unmeasured memory minimum or GPU speedup is claimed.

Yes: they are version 0.10.1 application windows captured with experimental TP194 data, ¹H/CDCl₃, experiments 10–32. Settings and library views are labelled. MwOSY shows an exploratory PS conversion, not a validated identity or absolute mass. The ResinAtOnce guide retains its separate DEMO screenshots, clearly labelled as simulated.

No. The documented operational route uses processed Bruker 1r data and compatible ramps. SPEN and ultrafast require sequence-specific spatial reconstruction and kernels. The example library inspects published data; it does not automatically reconstruct their FID.

No. Import, inspection and calculation do not rewrite original spectra. Alignment or b recalibration creates a derived copy and archives the previous state. Keep originals and projects; fingerprints allow input changes to be detected.

No. You can calculate D without an internal standard if b encoding is reviewed. Results and reports state that no standard was used. Rh and Mw may require viscosity and other conditions even when D is calculable.

Several substances can occur in that region. Confirm the added standard’s identity, region and attenuation. Rh = 3.65 Å belongs to the supplied laboratory protocol; it is not an identification by chemical shift.

Each standard has local D, expected D and a factor. Prime checks overlap and disagreement before combining compatible factors using a geometric mean. Disagreements are not hidden, and each signal is not separately forced to its expected value.

In Prepare DOSY / MwOSY review Medium / temperature or η(Tref) beside the standard. Accept fixed η at 293 K if appropriate, choose variable η or supply a manual measurement. Confirm identity and conditions. Without documented Rh, provide a sourced manual expected D; do not invent a radius.

No. Detection reads metadata; it does not measure Gmax or mixture viscosity. Check sequence, b, temperature and applicability. The shared experimental TBO calibration is not replaced with nominal gradient strength.

It must not. fReference, fTemperature and their product are stored and applied once to the D axis. Reviewing η(Tref) is distinct from enabling thermal normalisation. Check saved-result factors, not just current checkboxes.

No column passes the current attempt’s screening. Review the diagnostic: unestimable noise, too few useful points, negatives, growth, insufficient b coverage or exclusions. The previous map is not erased. Do not relax requirements merely to obtain an image.

The method has not satisfied its stopping criteria in that calculation. The iterate may be useful diagnostically but is not an approved solution. Review parameters, coverage and residuals; more iterations do not guarantee identifiability.

Not necessarily: their objectives and regularisation differ. Compare identical signed data, grid and calibration, plus prediction and residuals. This version uses a modified in-house dual-Newton MaxEnt implementation; a narrow or broad curve alone does not establish composition.

A band comes from a projection over many ppm positions. A peak calculation integrates a specific region. To compare algorithms use Local signal · TRAIn / compare with identical inputs and parameters, distinguishing measured from corrected D.

D only calculates a monoexponential fit and draws a marker. Use Calculate D / Mw and distribution for an actual distribution. A single D does not determine width or dispersity.

Restrict calculation to a relevant region or increase points per bin after reviewing lost resolution. Choose suitable method and grid, and compare a small case before running a batch. Save parameters. Do not interpret an overfitted smaller residual as a guaranteed improvement.

The logarithm is not calculated for invalid points or I≤0. They remain in the table with a reason and are not replaced by zero. Linear-tab masks do not clip the signed data used by inversions.

No. Selecting points by R² can bias the result and hide an inadequate model. Prime limits exclusions, retains comparison with all valid points and records the mask. Review physical reasons, not just the R² number.

No. PS and PPG are two high-dilution calibrations. There is also one empirical concentration model developed with PS. Applying it to other families requires justification; no universal validation is claimed.

First solute; second solute + solvent. Solvent mass is the difference. Quantities with units are read from the title of the first experiment in the ramp. Missing or ambiguous quantities remain empty and are requested when using concentration.

Not in general. Since Rh is proportional to 1/D, mean radius differs from the radius of mean D. Prime distinguishes monoexponential effective Rh from distribution mean Rh, with the viscosity and temperature used.

Not automatically. Moments are signal-weighted; proton response, relaxation, suppression, overlap and regularisation can affect areas. Interpreting an index as dispersity requires the appropriate model and weighting. Quantitative NMF unmixing is a research topic, not an already validated feature.

It is a shape clue, not an identification. Overlap, exchange, heterogeneity and processing can also broaden signals. Review the spectrum, other resonances, attenuation and chemical evidence before assigning.

The model retains positive unfitted signal and declares visually added area. Projection follows the active representation. Full range and Fit signals only reframe; they must not disable modelling or erase results. Review residual, threshold and original signal.

No: it proposes documentary hypotheses for the current selection, with sources and checks. A phthalic candidate can be compatible without establishing a free or bound species or concentration. No catalogue match does not rule out a substance either.

Current parameters or acquisition are not those that produced the saved result. Recover map parameters to retain it, or recalculate with the edits. Beatrix must not mix historical values with the current selection.

No. Alignment compensates reviewable spectral shifts; it does not remove material transport or alter kernel physics. Convection requires its own diagnosis and evidence.

If conditions, ramps or evidence are missing, a binary answer would be invented. Inconclusive preserves that uncertainty. Only a compatible, accepted review can provide a corrected final D for the signal and be documented in the report.

They are not presented as complete validated workflows. R&D modes and published experimental packages are available for inspection, but specific reconstruction remains pending. The user’s new ultrafast DOSY sequence is untested; UF-DEXSY does not validate it.

Record executable version, ramp, ppm region, method, parameters, full message and use of standards/temperature. Keep an example project and manifest; remove sensitive data before sharing. A local-method error is not the same as an HTTP connection failure.