Understand the measurement
Synchronized molecules, phases, vector sums and echo; coherence builder and 93 guided steps with predictions, units and calculations.
Software and training /
DIFFATONCE ACADEMY · 1.2.0
Understand before interpreting.
Learn diffusion NMR from molecular motion to map interpretation. Explain each decision, derive the equations and test your reasoning with interactive examples.
Complete ES / EN course · No web account required · Local progress and notebook
NEW · DOCTORAL LABORATORY
Predict. Check. Defend.
Nine activities connect physical mechanisms, experimental decisions and evidence. A public Bruker case takes you from the FID to a bounded conclusion.
Resolve the difficulties
Virtual calibration and acquisition budget, hidden causes and discriminating controls. Compare fits, ILT regularization, joint analysis and conditional uncertainty.
Support a conclusion
Process 16 real FIDs with attribution and hashes. Investigate a changing sample with sequential acquisition and UF/SPEN models. Export evidence for human assessment.
Real data: Silva, McKay and Junkers, Monash/Figshare, DOI10.26180/33075584.v1, CC BY4.0. Saved b and fitted D remain nominal/conditional, not absolute calibration. New hints use reviewed documentary content without LLM generation.
A COURSE FOR THINKING AND DOING
Every difficulty has an explanation.
Start with the meaning of D and progress to acquisition, fitting and reconstruction. Each lesson explains why it happens, what it is for and how to check it.
From instrument to map
Preparation, P90, gradients, p30/d20, LED, double stimulated echo, convection, processing, overlap, ILT and spectral correlations.
Learn from failure too
Examples and counterexamples with editable parameters, questions with feedback and a notebook to document your reasoning.
Physics you can explore
Brownian motion, phase encoding, convection, ultrafast, SPEN-DOSY, time-resolved diffusion, exchange and restrictions.
Known versus recovered
90° pulse, gradient scale, δ/Δ selection, velocity dispersion and ILT kernel conditioning. Export the synthetic calculations.
20 derivation chapters
Differential equations, magnetization, effective gradients, phase evolution and attenuation. Symbols, units, assumptions and source equation mapping.
The workshop, with context
Images, text and speaker notes from DOSY in practice, plus a method catalogue with objectives, uses and limits.
FROM GRADIENT TO EQUATION
The pulse program matters.
The physical pulse and effective gradient are different quantities. Study how q(t) evolves, integrate b and check the assumptions needed before reusing a formula.
Study the derivations →- From Bloch to Bloch–Torrey
- Gradient accumulates phase; diffusion destroys coherence
- q(t) = γ ∫ Geff(t) dt
- b = ∫ q²(t) dt
- PGSE, LED and double echo: check timings and signs
TWO EDITIONS, ONE COURSE
Choose where to learn.
BROWSER · HTML / JS
Academy Online
The complete educational pathway and simulations, served from a conventional website. Numeric operations run in your browser.
- Lessons, derivations, exercises and methods
- Progress and notebook stored locally
- Result exports and scene videos
- Web edition without Beatrix
WINDOWS · WPF · ES / EN
Academy + Beatrix
The desktop application retains locally fine-tuned Beatrix for the original 24 lessons. Answers about the 20 paper-based derivation chapters use a reviewed documentary guide with references, without LLM generation.
- Local Beatrix with sources
- Offline course, simulations and derivations
- Approximately 2 GB download with the model included
- Extract the ZIP before running
Training with simulations and attributed historical material. The program does not operate the spectrometer, replace an experimental calibration or turn a good fit into chemical identification.
DIFFATONCE / MOLECULAR DIFFUSION